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It's not just fat loss.
It's what happens to collagen when IGF-1 drops.
When you lose weight rapidly on a GLP-1 medication, your body does something that most people aren't warned about: it significantly reduces levels of IGF-1 — insulin-like growth factor 1
An anabolic hormone that your skin depends on to keep producing collagen and elastin.
IGF-1 is what tells your skin's fibroblasts to do their job.
Fibroblasts are the cells that build and maintain the collagen scaffolding that keeps skin firm, elastic, and structurally supported.
When IGF-1 drops, fibroblast activity slows. The structural proteins that give your face its volume and tone start to degrade faster than your body can replace them.
At the same time, the facial fat pads, natural cushions in your cheeks, temples, and around your eyes, deflate quickly.
Your skin, which has been adapted to the volume beneath it, suddenly has less to hold on to.
The result is the appearance that's been trending on TikTok, discussed in dermatology offices, and analyzed in Harvard Health publications: hollow cheeks, shadowed eyes, softened jawlines.
A face that looks not just thinner, but older.
How it Works?
Most Popular Plans
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Takes 3 Minutes • No Commitment Upfront
$119/ Month
GLP-1 medications like Ozempic and Mounjaro quietly deplete the hormone that keeps your skin producing collagen. Sermorelin, prescribed by CoreAge Rx physicians, helps restore it - before the damage shows.
IF YOU'RE ON GLP-1 MEDICATIONS
You've lost the weight.
Don't lose your face with it.
The Root Cause...
5-minute online intake. No commitment.
Physician reviews your case within 24 hours.
The scale went down.
The mirror said something different.
What's happening...
"Ozempic face" - as dermatologists and plastic surgeons have begun calling it - refers to the hollowed, aged facial changes that can follow rapid weight loss on GLP-1 medications. Google searches for the term have increased by 4,600% since 2021. It is now one of the fastest-growing concerns among women on these medications.
You are not alone in this.
You put in the work. The GLP-1 medication did what it promised — the pounds came off, your clothes fit differently, your doctor was pleased.
But somewhere around month two or three, you noticed something in the mirror. Your cheeks looked a little hollower. Your jawline felt softer. The area under your eyes looked more shadowed than it used to. Maybe you told yourself you were imagining it. Maybe someone else noticed first.
You weren't imagining it. And it's not a reflection of your age, your health, or how much weight you still want to lose.
It's biology. And there's a name for what you're experiencing.
The frustrating part is this: you made the healthy choice. You're doing something remarkable for your metabolic health, your heart, your longevity. The medication is working.
What nobody told you — what most providers still don't tell patients proactively — is that rapid weight loss does something specific to your skin's hormonal environment that goes well beyond surface-level fat loss.
Understanding this is the first step to doing something about it.
This is why topical creams and dermal fillers, while useful, treat the downstream effects, they address what's already changed.
Sermorelin works upstream, at the hormonal level, to support the environment your skin needs to maintain itself during and after weight loss.
It does not stop all facial changes. Losing significant weight will always have some effect on your face.
But the women who support their growth hormone levels during their GLP-1 journey give their skin a fighting chance - from the inside out.
Physician-prescribed. Pharmacy-prepared.
Delivered to your door.
The CoreAge Rx Protocol
Adding sermorelin to your routine takes less than 5 minutes to start. Here's exactly how it works.
Sermorelin:
Your body's own
collagen support system, reactivated.
THE SOLUTION
Sermorelin is a prescription peptide — a small chain of amino acids — that works with your body's own biology, not against it.
Unlike synthetic growth hormone injections, sermorelin does not introduce external hormones into your system. Instead, it signals your pituitary gland to produce and release human growth hormone (HGH) naturally — in the same pulsatile pattern your body used when you were younger.
That HGH raises IGF-1. And higher IGF-1 means your skin has the signals it needs to keep building collagen, maintain elastin, and support the structural integrity of your face during the very period of rapid fat loss when those signals naturally decline.
Weeks 1–3: "Better sleep. Many patients notice improved sleep quality and slightly higher energy within the first few weeks."
Weeks 4–8: "Skin elasticity. Improvements in skin texture, firmness, and hydration become noticeable as IGF-1 levels respond to treatment."
Months 3–6: "Body composition shifts. Lean tissue support becomes more pronounced, and patients on concurrent GLP-1 therapy typically report that their weight loss outcomes feel more 'clean' — losing from the right places."
Sermorelin is not for everyone.
Here's how to know if it's right for you.
We believe in honest medicine. Sermorelin is a prescription peptide that requires physician evaluation — and our physicians will only prescribe it when it's genuinely appropriate. Here's a transparent look at who tends to benefit most, and who should look elsewhere.
Is this right for me?
What women on GLP-1 say after
adding sermorelin.
"My daughter noticed before I did. She said I looked tired all the time, even when I wasn't. I'd lost about 28 pounds on semaglutide and was proud of it. but yes, something had changed in my face. My physician walked me through exactly what was happening hormonally and it clicked immediately. Three months after starting sermorelin, my daughter said: 'Mom, you look like yourself again.' That was enough for me."
Jessie M.
On semaglutide for 6 mo
"I'd lost 32 pounds and I should have been thrilled. But every time I looked in the mirror, I just saw this tired, hollowed-out version of myself. My CoreAge doctor mentioned sermorelin when I was about to start my 3-month GLP-1 refill. Within about six weeks, I genuinely noticed a difference — not that my face was the same as before, but that my skin looked... alive again. I wish I'd started it on day one."
Jessica B.
On semaglutide for 8 mo
"I was skeptical. I read everything I could about sermorelin before I agreed to try it. Four months in: my sleep is dramatically better, my skin feels firmer, and I honestly feel better in my body than I have in years. The weight loss is great. Feeling like myself again is better."
Julia S.
On tirzepatide for 7 mo
